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Genome-wide association study of colorectal cancer identifies six new susceptibility loci

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2015

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10.1038/ncomms8138

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Nature Research (part of Springer Nature)
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Schumacher, Fredrick R., Stephanie L. Schmit, Shuo Jiao, Christopher K. Edlund, Hansong Wang, Ben Zhang, Li Hsu, et al. 2015. “Genome-Wide Association Study of Colorectal Cancer Identifies Six New Susceptibility Loci.” Nature Communications 6 (1). https://doi.org/10.1038/ncomms8138.

Abstract

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E - 08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41392051

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