Publication: Chain Length Scaling of Protein Folding Time
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Date
1996
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American Physical Society
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Gutin, A. M., V. I. Abkevich, and E. I. Shakhnovich. 1996. “Chain Length Scaling of Protein Folding Time.” Physical Review Letters 77 (27): 5433–36. https://doi.org/10.1103/physrevlett.77.5433.
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Abstract
Folding of protein-like heteropolymers into unique 3D structures is investigated using Monte Carlo simulations on a cubic lattice. We found that the folding time of chains of length N scales as N-lambda at the temperature of fastest folding. For chains with random sequences of monomers lambda approximate to 6, and for chains with sequences designed to provide a pronounced minimum of energy to their ground state conformation lambda approximate to 4. Folding at low temperatures exhibits a simple, Arrhenius-like behavior.
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