Publication:
Heparan sulphate proteoglycans: the sweet side of development

No Thumbnail Available

Date

2005

Published Version

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Research (part of Springer Nature)
The Harvard community has made this article openly available. Please share how this access benefits you.

Research Projects

Organizational Units

Journal Issue

Citation

Häcker, Udo, Kent Nybakken, and Norbert Perrimon. 2005. “Heparan Sulphate Proteoglycans: The Sweet Side of Development.” Nature Reviews Molecular Cell Biology 6 (7): 530–41. https://doi.org/10.1038/nrm1681.

Research Data

Abstract

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.

Description

Other Available Sources

Keywords

Terms of Use

Metadata Only

Endorsement

Review

Supplemented By

Referenced By

Related Stories