Publication: Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes
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2007
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American Society for Microbiology
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Bihl, F., M. Narayan, J. V. Chisholm, L. M. Henry, T. J. Suscovich, E. E. Brown, T. M. Welzel, et al. 2007. “Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi’s Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes.” Journal of Virology 81 (9): 4904–8. doi:10.1128/JVI.02509-06.
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Abstract
The cellular immunity against Kaposils sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HILA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
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