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The Evolution of Imprinted microRNAs and Their RNA Targets

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genes-11-01038.pdf (750.73 KB)

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2020-09-03

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10.3390/genes11091038

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MDPI AG
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Haig, David, Avantika Mainieri. "The Evolution of Imprinted microRNAs and Their RNA Targets." Genes 11, no. 9 (2020): 1038. DOI: 10.3390/genes11091038

Abstract

Mammalian genomes contain many imprinted microRNAs. When an imprinted miRNA targets an unimprinted mRNA their interaction may have different fitness consequences for the loci encoding the miRNA and mRNA. In one possible outcome, the mRNA sequence evolves to evade regulation by the miRNA by a simple change of target sequence. Such a response is unavailable if the targeted sequence is strongly constrained by other functions. In these cases, the mRNA evolves to accommodate regulation by the imprinted miRNA. These evolutionary dynamics are illustrated using the examples of the imprinted C19MC cluster of miRNAs in primates and C2MC cluster in mice that are paternally expressed in placentas. The 3′ UTR of PTEN, a gene with growth-related and metabolic functions, appears to be an important target of miRNAs from both clusters.

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Genetics(clinical), Genetics

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This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service

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https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37370960

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