Publication: Rassf Family of Tumor Suppressor Polypeptides
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2009
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American Society for Biochemistry and Molecular Biology
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Avruch, Joseph, Ramnik Xavier, Nabeel Bardeesy, Xian-feng Zhang, Maria Praskova, Dawang Zhou, and Fan Xia. 2008. “Rassf Family of Tumor Suppressor Polypeptides.” Journal of Biological Chemistry 284 (17): 11001–5. https://doi.org/10.1074/jbc.r800073200.
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Abstract
The Rassf1-6 polypeptides each contain a Ras/Rap association domain, which enables binding to several GTP-charged Ras-like GTPases, at least in vitro or when overexpressed. The Ras/Rap association domains are followed by SARAH domains, which mediate Rassf heterodimerization with the Mst1/2 protein kinases. Rassf1A is unequivocally a tumor suppressor, and all Rassf proteins behave like tumor suppressors, exhibiting epigenetic silencing of expression in many human cancers and proapoptotic and/or anti-proliferative effects when re-expressed in tumor cell lines. Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function.
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