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Genome-wide association study of prostate cancer-specific survival

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2015

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10.1158/1055-9965.EPI-15-0543

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American Association for Cancer Research
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Szulkin, R., R. Karlsson, T. Whitington, M. Aly, H. Gronberg, R. A. Eeles, D. F. Easton, et al. 2015. “Genome-Wide Association Study of Prostate Cancer-Specific Survival.” Cancer Epidemiology Biomarkers & Prevention 24 (11): 1796–1800. https://doi.org/10.1158/1055-9965.epi-15-0543.

Abstract

Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study.Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292457

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