Publication: Genome-wide association study of prostate cancer-specific survival
No Thumbnail Available
Open/View Files
Date
2015
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
American Association for Cancer Research
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Szulkin, R., R. Karlsson, T. Whitington, M. Aly, H. Gronberg, R. A. Eeles, D. F. Easton, et al. 2015. “Genome-Wide Association Study of Prostate Cancer-Specific Survival.” Cancer Epidemiology Biomarkers & Prevention 24 (11): 1796–1800. https://doi.org/10.1158/1055-9965.epi-15-0543.
Research Data
Abstract
Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study.Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.
Description
Other Available Sources
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles (OAP), as set forth at Terms of Service