Publication: Characterization of Nucleic Acids by Nanopore Analysis
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Date
2002
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American Chemical Society
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Deamer, David W. and Daniel Branton. 2002. Characterization of nucleic acids by nanopore analysis. Accounts of Chemical Research 35(10): 817-825.
Abstract
Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.
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