Publication: A One-Step Synthesis of Pseudoephedrine Glycinamide, a Versatile Precursor for the Synthesis of a-Amino Acids
Date
1995
Published Version
Journal Title
Journal ISSN
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Publisher
Elsevier
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Citation
Myers, Andrew G., Taeyoung Yoon, and James L. Gleason.
Research Data
Abstract
Both enantiomers of a pseudoephedrine glycinamide [(+)- or (-)-1] were synthesized by either of two procedures: (1) a standard two-step coupling of N-Boc-Gly with pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with pseudoephedrine mediated by LiCl and base.
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Keywords
one-step synthesis, alpha amino acid, glycinamide, pseudoephedrine
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