Publication: Synthesis of Highly Enantiomerically Enriched N-Boc-a-amino Ketones from Pseudoephedrine N-Boc-a-amino Acid Amides
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1995
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Elsevier
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Myers, Andrew G. and Taeyoung Yoon. 1995. Synthesis of highly enantiomerically enriched N-Boc-a-amino ketones from pseudoephedrine N-Boc-a-amino acid amides. Tetrahedron Letters 36(52): 9429-9432.
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Abstract
N-Boc-alpha-amino ketones are synthesized efficiently and in high enantiomeric excess by the addition of organolithium and Grignard reagents to pseudoephedrine amides of N-Boc-alpha-amino acids, themselves available by the alkylation of pseudoephedrine glycinamide followed by N-protection.
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