Publication: A Concise Synthesis of the Naphthoic Acid Component of Neocarzinostatin Chromophore Featuring a New Photocyclization Reaction
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Date
1995
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Elsevier
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Citation
Myers, Andrew G., Vijaya Subramanian and Marlys Hammond. 1995. A concise synthesis of the naphthoic acid component of neocarzinostatin chromophore featuring a new photocyclization reaction. Tetrahedron Letters 37(5): 587-590.
Abstract
A 6-step synthesis of the naphthoic acid component of the natural antitumor agent neocarzinostatin chromophore is described. The synthetic route employs a 4-bromo-3-methylanisole as the starting material, proceeds in 31-37% yield for the 6 steps, and features as the key step a photocyclization reaction that is an interesting variant of known photocyclization reactions of stilbenes and phenylbutadienes.
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Keywords
chromophore, naphthoic acid, neocarzinostatin, photocyclization
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