Publication: Enantioselective Synthesis of (+)-Cephalostatin 1
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Date
2010
Published Version
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Publisher
American Chemical Society
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Citation
Fortner, Kevin, Darryl Kato, Yoshiki Tanaka, Matthew David Shair. 2010. Enantioselective Synthesis of (+)-Cephalostatin 1. Journal of the American Chemical Society 132(1): 275-280.
Research Data
Abstract
This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C−H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.
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Keywords
natural product, total synthesis, antiproliferative, cephalostatin
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