Publication: Cytological profiling: providing more haystacks for chemists' needles
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Date
2005
Authors
Published Version
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Publisher
BioMed Central
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Citation
Lorang, Janet and Randall W. King. 2005. Cytological profiling: providing more haystacks for chemists' needles. Genome Biology 6(8): 228.
Research Data
Abstract
Conventional high-throughput ‘chemical genetic’ screening seeks to identify small-molecule
inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of
cellular morphology, followed by affinity purification to identify targets of compounds with
interesting effects, can lead to the identification of novel inhibitors.
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Keywords
Biotechnology, Applied Microbiology, Genetics, Heredity
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