Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update
Open/View files
Date
2009
Author(s)
Bennett, Diane E.
Camacho, Ricardo J.
Otelea, Dan
Fleury, Hervé
Kiuchi, Mark
Heneine, Walid
Kantor, Rami
Jordan, Michael R.
Schapiro, Jonathan M.
Vandamme, Anne-Mieke
Sandstrom, Paul
van de Vijver, David
Rhee, Soo-Yon
Liu, Tommy F.
Pillay, Deenan
Shafer, Robert W.
Publisher
Public Library of Science
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Bennett, Diane E., Ricardo J. Camacho, Dan Otelea, Daniel R. Kuritzkes, Hervé Fleury, Mark Kiuchi, Walid Heneine, et al. 2009. Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update. PLoS ONE 4(3): e4724.
Abstract
Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately compare transmitted drug resistance rates across geographic regions and times, the World Health Organization has recommended the adoption of a consensus genotypic definition of transmitted HIV-1 drug resistance. In January 2007, we outlined criteria for developing a list of mutations for drug-resistance surveillance and compiled a list of 80 RT and protease mutations meeting these criteria (surveillance drug resistance mutations; SDRMs). Since January 2007, several new drugs have been approved and several new drug-resistance mutations have been identified. In this paper, we follow the same procedures described previously to develop an updated list of SDRMs that are likely to be useful for ongoing and future studies of transmitted drug resistance. The updated SDRM list has 93 mutations including 34 NRTI-resistance mutations at 15 RT positions, 19 NNRTI-resistance mutations at 10 RT positions, and 40 PI-resistance mutations at 18 protease positions.
Other Available Sources
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service
Collection