Publication: Role of BRCA Gene Dysfunction in Breast and Ovarian Cancer Predisposition
Open/View Files
Date
2000
Authors
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Scully, Ralph. 2000. Role of BRCA gene dysfunction in breast and ovarian cancer predisposition. Breast Cancer Research 2(5): 324-330.
Research Data
Abstract
Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major hereditary breast/ovarian cancer predisposition genes, BRCA1 and BRCA2, appear to participate in a common pathway that is involved in the control of homologous recombination and in the maintenance of genomic integrity. How might such functions translate into the specific suppression of cancers of the breast and ovarian epithelia? Recent advances in the study of BRCA1 and BRCA2, discussed herein, have provided new opportunities to address this question.
Description
Other Available Sources
Keywords
breast cancer, DNA repair, homologous recombination, ovarian cancer, tumor suppressor genes
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service