Publication: Analysis of genetic systems using experimental evolution and whole-genome sequencing
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Date
2007
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BioMed Central
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Citation
Hegreness, Matthew and Roy Kishony. 2007. Analysis of genetic systems using experimental evolution and whole-genome sequencing. Genome Biology 8(1): 201.
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Abstract
The application of whole-genome sequencing to the study of microbial evolution promises to reveal the complex functional networks of mutations that underlie adaptation. A recent study of parallel evolution in populations of Escherichia coli shows how adaptation involves both functional changes to specific proteins as well as global changes in regulation.
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Keywords
From Thomson ISI Web of Knowledge Keywords Plus:, Term Experimental Evolution, Escherichia-Coli Populations, Mutation Rate, Caenorhabditis-Elegans, Beneficial Mutations, Clonal Interference, Adaptive Evolution, 20,000 Generations, Parallel Changes, DNA
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