Publication: Polymorphic repeat in AIB1 does not alter breast cancer risk
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Date
2000
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BioMed Central
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Haiman, Christopher A., Susan E. Hankinson, Donna Spiegelman, Graham A. Colditz, Walter C. Willett, Frank E. Speizer, Myles Brown, and David J. Hunter. 2000. Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Research 2(5): 378-385.
Abstract
We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association between AIB1 genotype and breast cancer incidence, or specific tumor characteristics. These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population.
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Keywords
AIB1 polymorphism, breast cancer, genetic susceptibility, molecular epidemiology
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