Publication: The Prolyl Isomerase Pin1 in Breast Development and Cancer
Loading...
Open/View Files
Date
2003
Published Version
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Wulf, Gerburg, Akihide Ryo, Yih-Cherng Liou, and Kun Ping Lu. 2003. The prolyl isomerase Pin1 in breast development and cancer. Breast Cancer Research 5(2): 76-82.
Abstract
The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin D1 and transformation of breast epithelial cells in collaboration with the oncogenic pathways. In contrast, inhibition of Pin1 can suppress the transformation of breast epithelial cells. In addition, Pin1 knockout in mice prevents massive proliferation of breast epithelial cells during pregnancy. Pin1 plays a pivotal role in breast development and may be a promising new anticancer target.
Description
Other Available Sources
Research Data
Keywords
breast cancer, breast development, cyclin D1, phosphorylation signaling, Pin1
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service