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Re-evaluating Early Breast Neoplasia

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2008

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BioMed Central
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Moulis, Sharon and Dennis C. Sgroi. 2008. Re-evaluating early breast neoplasia. Breast Cancer Research 10(1): 302.

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Historically, histomorphological and epidemiological data suggested that atypical ductal hyperplasia and ductal carcinoma in situ are the earliest recognizable neoplastic stages of breast cancer progression. Over the past several years, detailed high-throughput molecular genetic, gene expression and epigenetic analyses have enhanced our understanding of these early neoplastic lesions and have re-shaped our view of human breast cancer progression to include multiple distinct pathways of evolution.

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