Publication: Carbon–Fluorine Bond Formation
Open/View Files
Date
2008
Published Version
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
Current Drugs Ltd.
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Furuya, Takeru, Christian A. Kuttruff, and Tobias Ritter. 2008. Carbon–fluorine bond formation. Current Opinion in Drug Discovery and Development 11(6): 803–819.
Research Data
Abstract
We present a selection of carbon–fluorine bond formations that have been developed in the recent past. An overview of the most common fluorination reagents is followed by fluorination reactions organized by reactivity. We have distinguished between nucleophilic and electrophilic fluorinations as well as aliphatic and aromatic fluorinations. Each section is divided into more specific reaction classes and examples for syntheses of pharmaceuticals, \(^{18}\)F-radiolabeling, and mechanistic investigations are provided.
Description
Other Available Sources
Keywords
fluorination, carbon-fluorine bond formation, nucleophilic fluorination, electrophilic fluorination, fluorinating reagents, enantioselective fluorination
Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles (OAP), as set forth at Terms of Service