Publication: Regulation of the Final Stage of Mitosis by Components of the Pre-Replicative Complex and a Polo Kinase
Open/View Files
Date
2011
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
Landes Bioscience
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Yim, Hyungshin, and Raymond Leo Erikson. 2011. Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase. Cell Cycle 10(9): 1374-1377.
Research Data
Abstract
The accurate division of duplicated DNA is essential for maintenance of genomic stability in proliferating eukaryotic cells. Errors in DNA replication and chromosomal segregation may lead to cell death or genomic mutations that lead to oncogenic properties. Thus, tight regulation of DNA replication and mitosis is essential for maintaining genomic integrity. Cell division cycle 6 (Cdc6) is an essential factor for initiating DNA replication. Recent work shows that phosphorylation of Cdc6 by polo-like kinase 1 (Plk1), one of the essential mitotic kinases, regulates mitotic exit mediated by Cdk1 and separase. Here we discuss how pre-replicative complex factors are connected with Plk1 and affect mitotic exit.
Description
Other Available Sources
Keywords
polo-like kinase 1, cell division cycle 6, DNA replication, mitotic exit, chromosomal segregation
Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles (OAP), as set forth at Terms of Service