Publication:

The Molecular Clockwork of a Protein-Based Circadian Oscillator

Thumbnail Image

Open/View Files

MolecularClockwork.pdf (10.72 MB)

Date

2009

Authors

Published Version

10.1016/j.febslet.2009.11.021

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier
The Harvard community has made this article openly available. Please share how this access benefits you.

Research Projects

Organizational Units

Journal Issue

Citation

Markson, Joseph Scott and Erin K. O'Shea. The molecular clockwork of a protein-based circadian oscillator. FEBS Letters 583(24): 3938-3947.

Abstract

The circadian clock of the cyanobacterium Synechococcuselongatus PCC 7942 is governed by a core oscillator consisting of the proteins KaiA, KaiB, and KaiC. Remarkably, circadian oscillations in the phosphorylation state of KaiC can be reconstituted in a test tube by mixing the three Kai proteins and adenosine triphosphate. The in vitro oscillator provides a well-defined system in which experiments can be combined with mathematical analysis to understand the mechanism of a highly robust biological oscillator. In this Review, we summarize the biochemistry of the Kai proteins and examine models that have been proposed to explain how oscillations emerge from the properties of the oscillator’s constituents.

Description

Other Available Sources

Research Data

Keywords

Terms of Use

This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service

URI

http://nrs.harvard.edu/urn-3:HUL.InstRepos:8841743

Collections

FAS Scholarly Articles

Endorsement

Review

Supplemented By

Related Stories