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IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus Infection

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3316688.pdf (663.21 KB)

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2012

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10.1371/journal.pone.0034508

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Public Library of Science
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Chan, Ying Kai, I-Chueh Huang, and Michael Farzan. 2012. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE 7(3): e34508.

Abstract

Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316688/pdf/

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Biology, Immunology, Immunity, Microbiology, Virology, Viral Classification, Medicine, Infectious Diseases, Neglected Tropical Diseases, Viral Diseases

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:10344717

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