Publication:

SIRT2 as a Therapeutic Target for Age-Related Disorders

Thumbnail Image

Open/View Files

3342661.pdf (817.75 KB)

Date

2012

Authors

Published Version

10.3389/fphar.2012.00082

Journal Title

Journal ISSN

Volume Title

Publisher

Frontiers Research Foundation
The Harvard community has made this article openly available. Please share how this access benefits you.

Research Projects

Organizational Units

Journal Issue

Citation

de Oliveira, Rita Machado, Jana Sarkander, Aleksey G. Kazantsev, and Tiago Fleming Outeiro. 2012. SIRT2 as a therapeutic target for age-related disorders. Frontiers in Pharmacology 3:82.

Abstract

Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life such as cancer, diabetes, cardiovascular, and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function. SIRT1 has received much of attention due to its possible impact on longevity, while important biological and therapeutic roles of other sirtuins have been underestimated and just recently recognized. Here we focus on SIRT2, a member of the sirtuin family, and discuss its role in cellular and tissue-specific functions. This review summarizes the main scientific advances on SIRT2 protein biology and explores its potential as a therapeutic target for treatment of age-related disorders.

Description

Other Available Sources

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342661/pdf/

Research Data

Keywords

SIRT2, aging, metabolic syndrome, cancer, neurodegenerative disorder

Terms of Use

This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service

URI

http://nrs.harvard.edu/urn-3:HUL.InstRepos:10368162

Collections

HMS Scholarly Articles

Endorsement

Review

Supplemented By

Related Stories