Publication: IRE1α Activation Protects Mice Against Acetaminophen-Induced Hepatotoxicity
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Date
2012
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The Rockefeller University Press
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Hur, Kyu Yeon, Jae-Seon So, Vera Ruda, Maria Frank-Kamenetsky, Kevin Fitzgerald, Victor Koteliansky, Takao Iwawaki, Laurie H. Glimcher, and Ann-Hwee Lee. 2012. IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. The Journal of Experimental Medicine 209(2): 307-318.
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Abstract
Mice lacking the transcription factor XBP1 exhibit constitutive activation of the stress sensor IRE1α and are protected from acetaminophen overdose–induced acute liver failure.
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