Publication: Retinoic acid-producing DCs and gut-tropic \(FOXP3^+\) regulatory T cells in the induction of oral tolerance
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Date
2013
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Publisher
Landes Bioscience
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Citation
Villablanca, Eduardo J. 2013. Retinoic acid-producing DCs and gut-tropic \(FOXP3^+\) regulatory T cells in the induction of oral tolerance. Oncoimmunology 2(2): e22987.
Research Data
Abstract
The systemic unresponsiveness of the immune system to orally administered antigens is known as oral tolerance. Recent findings describe a new step for the induction of oral tolerance, consisting in the homing of \(FOXP3^+\) regulatory T cells to the small bowel and the local acquisition of full immunosuppressive capacities, a process in which retinoic acid-producing dendritic cells might play a crucial role.
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Keywords
FOXP3, dendritic cells, gut homing, oral tolerance, retinoic acid
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