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Chronopharmacology of Anti-Convulsive Therapy

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3607723.pdf (276.84 KB)

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2013

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10.1007/s11910-013-0339-2

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Current Science Inc.
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Ramgopal, Sriram, Sigride Thome-Souza, and Tobias Loddenkemper. 2013. Chronopharmacology of anti-convulsive therapy. Current Neurology and Neuroscience Reports 13(4): 339.

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Abstract

Approximately one-third of patients with epilepsy continue to have seizures despite antiepileptic therapy. Many seizures occur in diurnal, sleep/wake, circadian, or even monthly patterns. The relationship between biomarkers and state changes is still being investigated, but early results suggest that some of these patterns may be related to endogenous circadian patterns whereas others may be related to wakefulness and sleep or both. Chronotherapy, the application of treatment at times of greatest seizure susceptibility, is a technique that may optimize seizure control in selected patients. It may be used in the form of differential dosing, as preparations designed to deliver sustained or pulsatile drug delivery or in the form of ‘zeitgebers’ that shift endogenous rhythms. Early trials in epilepsy suggest that chronopharmacology may provide improved seizure control compared with conventional treatment in some patients. The present article reviews chronopharmacology in the treatment of epilepsy as well as future treatment avenues.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607723/pdf/

Keywords

Epilepsy, Chronotherapy, Chronopharmacology, Chronopharmacokinetics, Differential dosing, Seizures, Seizure patterns, Diurnal patterns, Closed loops, Melatonin, Light therapy, Dim light melatonin onset, DLMO, Circadian rhythms, Circadian pattern, Suprachiasmatic nucleus, Seizure tracking, Seizure diary, Chronopharmacodynamics, Pharmacokinetics, Pharmacodynamics

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:10627603

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Chronopharmacology of Anti-Convulsive Therapy… : DASH Story 2015-01-11
My husband has intractable epilepsy, made 300x worse by temporal lobectomy for dysplasia. Our neurologist is not proactive about researching treatments and the prescribed drugs only treat the manifestation of seizures without affecting the disease. Using this type of free access research we have been able to introduce well researched phytonutrients like curcumin and grape seed extract phytosomes. Knowing that virtually 100% of Luke's seizures occur within an hour of awaking, we are currently researching chronopharmacological approaches. Luke's quality of life has improved immeasurably due to our ability to research and safely try out photochemical supplements - implementing a low dose anti inflammatory protocol that trending research shows holds hope for a cure. Who knows, some day Luke may be able to return to an interrupted journalist career; when that happens it will be because we were empowered by the research to continuously seek improvement over the status quo.