Publication: Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
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Date
2013
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Springer Netherlands
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Earnshaw, W. C., R. C. Allshire, B. E. Black, K. Bloom, B. R. Brinkley, W. Brown, I. M. Cheeseman, et al. 2013. Esperanto for histones: cenp-a, not cenh3, is the centromeric histone h3 variant. Chromosome Research 21(2): 101-106.
Abstract
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
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Keywords
centromere, CENP-A, histone, kinetochore, CenH3
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