Publication: Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium
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Date
2012
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Public Library of Science
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Citation
Lau, Ken S., Virna Cortez-Retamozo, Sarah R. Philips, Mikael J. Pittet, Douglas A. Lauffenburger, and Kevin M. Haigis. 2012. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. PLoS Biology 10(9): e1001393.
Abstract
An intercellular communication network that controls intestinal homeostasis in animals treated acutely with the pro-inflammatory cytokine TNF-α is uncovered by multi-scale systems analysis.
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Keywords
Biology, Computational Biology, Signaling Networks, Model Organisms, Animal Models, Systems Biology
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