Publication: High-throughput approaches to discover novel immunomodulatory agents for cancer
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Date
2012
Published Version
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Volume Title
Publisher
Landes Bioscience
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Citation
McMillin, Douglas William, and Constantine S. Mitsiades. 2012. High-throughput approaches to discover novel immunomodulatory agents for cancer. Oncoimmunology 1(8): 1406-1408.
Research Data
Abstract
The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell activity. We documented that the interaction between cancer cells, their stroma, anticancer agents and cells from the innate system are critical for determining the response of tumors to immunomodulatory strategies.
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Keywords
cancer, high-throughput screening, immune effector cells, pharmacological immunomodulators, tumor heterogeneity
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