Publication:
Diagnosis of Influenza from Lower Respiratory Tract Sampling after Negative Upper Respiratory Tract Sampling

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2013

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Landes Bioscience
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Bogoch, Isaac, Jason Randolph Andrews, Kimon C. Zachary, and Elizabeth Louise Hohmann. 2013. Diagnosis of influenza from lower respiratory tract sampling after negative upper respiratory tract sampling. Virulence 4(1): 82-84.

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Abstract

In this retrospective cohort study, we demonstrate that PCR-confirmed diagnoses of influenza were made solely by lower respiratory sampling in 6.9% of cases, as traditional upper respiratory tract tests were negative, indeterminate or not performed. Clinical features of these cases are presented. Clinicians should consider lower respiratory tract sampling in select cases of influenza-like illness for diagnosis.

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influenza, human, H1N1 virus, bronchoalveolar lavage, polymerase chain reaction

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