Publication: New players on the metabolic stage
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Date
2013
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Landes Bioscience
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Citation
Cohen, David E. 2013. New players on the metabolic stage. Adipocyte 2(1): 3-6.
Abstract
Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly upregulated when mice are exposed to cold ambient temperatures. In a recent study, we demonstrated that Them1−/− mice exhibit increased energy expenditure and are resistant to diet-induced obesity and its metabolic consequences. This mini-review places these findings in the context of an emerging understanding of Them/Acot genes.
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Keywords
brown adipose tissue, liver, enzyme, fatty acyl-CoA, lipid binding protein
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