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Nickel-Mediated Oxidative Fluorination for PET with Aqueous [\(^{18}F\)] Fluoride

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2012

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American Chemical Society
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Lee, Eunsung, Jacob M. Hooker, and Tobias Ritter. 2012. Nickel-mediated oxidative fluorination for PET with aqueous [\(^{18}F\)] Fluoride. Journal of the American Chemical Society 134 (42): 17456-17458.

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Abstract

A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical \(^{18}F\) late-stage fluorination of complex small molecules with potential for PET imaging.

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positron emission tomography

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