Publication: Mechanisms of Transcriptional Control in Phosphate-responsive Signaling Pathway of Saccharomyces cerevisiae
Open/View Files
Date
2013-10-08
Authors
Published Version
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Zhou, Xu. 2013. Mechanisms of Transcriptional Control in Phosphate-responsive Signaling Pathway of Saccharomyces cerevisiae. Doctoral dissertation, Harvard University.
Research Data
Abstract
Regulation of gene expression is essential for many biological processes. Binding of transcription factors to DNA is a key regulatory step in the control of gene expression. It is commonly observed that DNA sequences with high affinity for transcription factors occur more frequently in the genome than the instances of genes bound or regulated by these factors. However, the mechanism by which transcription factors selectively identify and regulate these genes was unclear. I utilized the transcriptional control of the phosphate-responsive signaling pathway (PHO) in Saccharomyces cerevisiae as a model system to address this problem.
Description
Other Available Sources
Keywords
Systematic biology, Molecular biology, Genetics, chromatin structure, competition, cooperativity, PHO respnose, systematic dissection, transcriptional control
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service