Publication: Human Vascular Endothelium from Induced Pluripotent Stem Cells
Open/View Files
Date
2013-10-08
Authors
Published Version
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Adams, William James. 2013. Human Vascular Endothelium from Induced Pluripotent Stem Cells. Doctoral dissertation, Harvard University.
Research Data
Abstract
The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-derived endothelial cells remains poorly understood.
Description
Other Available Sources
Keywords
Biomedical engineering, Cellular biology, endothelium, induced pluripotent stem cells
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service