Publication: Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling
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2013-10-15
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Shao, Diane Donghui. 2013. Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling. Doctoral dissertation, Harvard University.
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Abstract
Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic addiction." By using unbiased genetic tools to functionally probe oncogenic addiction, we can identify cancer dependencies and characterize aspects of oncogenic signaling.
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Cellular biology, Genetics, ATARiS, HNF1B, RAS, RNAi, YAP
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