Publication: Evolutionary Adaptation and Antimalarial Resistance in Plasmodium falciparum
Loading...
Open/View Files
Date
2013-10-14
Authors
Published Version
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Park, Daniel John. 2013. Evolutionary Adaptation and Antimalarial Resistance in Plasmodium falciparum. Doctoral dissertation, Harvard University.
Abstract
The malaria parasite, Plasmodium falciparum, has a demonstrated history of adaptation to antimalarials and host immune pressure. This ability unraveled global eradication programs fifty years ago and seriously threatens renewed efforts today. Despite the magnitude of the global health problem, little is known about the genetic mechanisms by which the parasite evades control efforts. Population genomic methods provide a new way to identify the mutations and genes responsible for drug resistance and other clinically important traits.
Description
Other Available Sources
Research Data
Keywords
Evolution & development, Genetics, Parasitology, drug resistance, evolution, genomics, GWAS, malaria, selection
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service