Publication: The Role of Dendritic Cell Subsets in Cross-presentation and Stimulation of Homing Marker Expression
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Date
2014-02-25
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Nizza, Suzanne Josette Taghap. 2014. The Role of Dendritic Cell Subsets in Cross-presentation and Stimulation of Homing Marker Expression. Doctoral dissertation, Harvard University.
Abstract
Topical antigen (Ag) application mimics natural Ag exposure across the skin. Soluble Ag introduced through this route requires cross-presentation by dendritic cells (DCs) to generate CD8 T cell responses, including skin-homing T cells. DCs process Ag for display to other immune cells, and stimulate T cells to release cytokines or directly lyse infected cells. Some T cells are further stimulated to express homing markers allowing them to enter non-lymphoid tissue such as the skin or the gut.
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Immunology, Cellular biology, Biology, Dendritic cells, Homing markers, Skin-homing, Subsets
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