Publication: Synthesis of [\(^{11}\)C]SSR149415 and Preliminary Imaging Studies Using Positron Emission Tomography
Date
2010
Published Version
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Publisher
Elsevier BV
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Citation
Schönberger, Matthias, Carmine Leggett, Sung Won Kim, and Jacob M. Hooker. 2010. “Synthesis of [11C]SSR149415 and Preliminary Imaging Studies Using Positron Emission Tomography.” Bioorganic & Medicinal Chemistry Letters 20 (10) (May): 3103–3106. doi:10.1016/j.bmcl.2010.03.108.
Research Data
Abstract
SSR149415 was the first non-peptide vasopressin-(V\(_{1b}\)) receptor antagonist reported. It has been used to probe the role of V\(_{1b}\) receptors in animal models of depression, aggression, and stress-anxiety, and was progressed to clinical trials for the treatment of depression. Due to the interest in V\(_{1b}\) receptors as a therapeutic target and the growing use of SSR149415 in preclinical research, we developed a method to label SSR145419 with carbon-11 and have studied its pharmacokinetics in non-human primates using positron emission tomography.
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Keywords
positron emission tomography, vasopressin, SSR149415, carbon-11
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