Publication: A Simple, Rapid Method for the Preparation of [11 C]Formaldehyde
Date
2008
Published Version
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Publisher
Wiley-Blackwell
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Citation
Hooker, Jacob M., Matthias Schönberger, Hanno Schieferstein, and Joanna S. Fowler. 2008. “A Simple, Rapid Method for the Preparation of [11C]Formaldehyde.” Angewandte Chemie International Edition 47 (32) (July 4): 5989–5992. doi:10.1002/anie.200800991.
Research Data
Abstract
A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules—[11C]formaldehyde—is accessible from [11C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. Easy access to [11C]formaldehyde expands the scope of the carbon-11 toolbox and will lead to new reaction methodology and imaging compounds.
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Keywords
formaldehyde, isotopic labeling, N-oxides, oxidation, positron emission tomography
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