Publication:

An Efficient and Practical Radiosynthesis of [11C] Temozolomide

Thumbnail Image

Date

2012

Authors

Published Version

10.1021/ol302791x

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society (ACS)
The Harvard community has made this article openly available. Please share how this access benefits you.

Research Projects

Organizational Units

Journal Issue

Citation

Moseley, Christian K., Stephen M. Carlin, Ramesh Neelamegam, and Jacob M. Hooker. 2012. “An Efficient and Practical Radiosynthesis of [11C]Temozolomide.” Organic Letters 14 (23) (December 7): 5872–5875. doi:10.1021/ol302791x.

Abstract

Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [11C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [11C]TMZ synthesis and reformulation make it difficult for routine production. A highly reproducible one-pot radiosynthesis of [11C]TMZ with a radiochemical yield of 17 ± 5% and ≥97% radiochemical purity is reported.

Description

Other Available Sources

Research Data

Keywords

Terms of Use

Metadata Only

URI

http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490452

Collections

FAS Scholarly Articles

Endorsement

Review

Supplemented By

Related Stories