Publication: Differences in white matter reflect atypical developmental trajectory in autism: A Tract-based Spatial Statistics study☆
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Date
2012
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Elsevier
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Citation
Bakhtiari, Reyhaneh, Nicole R. Zürcher, Ophélie Rogier, Britt Russo, Loyse Hippolyte, Cristina Granziera, Babak Nadjar Araabi, Majid Nili Ahmadabadi, and Nouchine Hadjikhani. 2012. “Differences in white matter reflect atypical developmental trajectory in autism: A Tract-based Spatial Statistics study☆.” NeuroImage : Clinical 1 (1): 48-56. doi:10.1016/j.nicl.2012.09.001. http://dx.doi.org/10.1016/j.nicl.2012.09.001.
Research Data
Abstract
Autism is a neurodevelopmental disorder in which white matter (WM) maturation is affected. We assessed WM integrity in 16 adolescents and 14 adults with high-functioning autism spectrum disorder (ASD) and in matched neurotypical controls (NT) using diffusion weighted imaging and Tract-based Spatial Statistics. Decreased fractional anisotropy (FA) was observed in adolescents with ASD in tracts involved in emotional face processing, language, and executive functioning, including the inferior fronto-occipital fasciculus and the inferior and superior longitudinal fasciculi. Remarkably, no differences in FA were observed between ASD and NT adults. We evaluated the effect of age on WM development across the entire age range. Positive correlations between FA values and age were observed in the right inferior fronto-occipital fasciculus, the left superior longitudinal fasciculus, the corpus callosum, and the cortical spinal tract of ASD participants, but not in NT participants. Our data underscore the dynamic nature of brain development in ASD, showing the presence of an atypical process of WM maturation, that appears to normalize over time and could be at the basis of behavioral improvements often observed in high-functioning autism.
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Keywords
ADOS, Autism Diagnostic Observation Schedule, ADI-R, Autism Diagnostic Interview-Revised, AQ, Autism Quotient, ASD, Autism Spectrum Disorders, ATR, anterior thalamic radiations, CC, corpus callosum, CT, corticospinal tract, DTI, Diffusion Tensor Imaging, DTT, Diffusion Tensor Tractography, EF, executive functions, FA, fractional anisotropy, IFOF, inferior froto-occipital fasciculus, ILF, inferior longitudinal fasciculus, NT, neurotypical, PIQ, Performance Intelligence Quotient, SLF, superior longitudinal fasciculus, TBSS, Tract-based Spatial Statistics, TFCE, Threshold-free Cluster Enhancement, TE, echo time, TR, repetition time, UNC, uncinate fasciculus, VBM, Voxel-Based Morphometry, VBS, Voxel based Statistics of FA Images (VBM-like), WM, white matter, Diffusion Tensor Imaging, Autism spectrum disorder, Brain connectivity, Fractional anisotropy, Brain development, Brain maturation
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