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Escape of DNA from a Weakly Biased Thin Nanopore: Experimental Evidence for a Universal Diffusive Behavior

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2013

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American Physical Society (APS)
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Hoogerheide, David, Fernando Albertorio, and Jene Golovchenko. 2013. “Escape of DNA from a Weakly Biased Thin Nanopore: Experimental Evidence for a Universal Diffusive Behavior.” Physical Review Letters 111 (24) (December).

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Abstract

We report experimental escape time distributions of double-stranded DNA molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of the experiment and the potential role of complex molecule-liquid-pore interactions. Diffusion constants that depend on the molecule length and pore size are determined. Also discussed are the practical implications of long time diffusive molecule trapping in the nanopore.

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