Publication: Synthetic Studies toward Hennoxazole A. Use of a Selective Bisoxazole Alkylation as the Key Fragment Coupling
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Date
2002
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Japan Institute of Heterocyclic Chemistry
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E. Smith, Thomas, and Emily P. Balskus. 2002. “Synthetic Studies Toward Hennoxazole A. Use of a Selective Bisoxazole Alkylation as the Key Fragment Coupling.” HETEROCYCLES 57 (7): 1219. doi:10.3987/com-02-9480.
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Abstract
A model system for side chain fragment coupling to the core of hennoxazole A is investigated. Lateral metallation of a C13-TBS-protected bisoxazole, using lithium diethylamide, allows for selective and efficient alkylation at C15.
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