Publication: Enantioselective Total Synthesis of Hyperforin
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Date
2013
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American Chemical Society
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Sparling, Brian A., David C. Moebius, and Matthew D. Shair. 2013. Enantioselective Total Synthesis of Hyperforin. Journal of the American Chemical Society 135, no. 2: 644–647.
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Abstract
A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.
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