Publication: Effector roles of Granulocytes and B cells during Th2 Inflammation
Date
2014-06-06
Authors
Published Version
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Dwyer, Daniel Francis. 2014. Effector roles of Granulocytes and B cells during Th2 Inflammation. Doctoral dissertation, Harvard University.
Research Data
Abstract
Allergens are complex mixes of proteins and other compounds that have innate signaling capacity leading to Th2 inflammation. Understanding the role of each of these signals is essential to determining what separates allergens from innocuous proteins. Here, we examine two models for Th2 inflammation: infection with the helminth Trichinella spiralis and footpad immunization with papain, a cysteine protease structurally similar to proteases found in many common allergens including grass pollen and dust mites and helminth-secreted proteases secreted. Together, these studies highlight previously unappreciated effector roles of accessory cells during Th2 inflammation.
Description
Other Available Sources
Keywords
Immunology, B cell, Granulocyte, Inflammation, Papain, Th2, T. spiralis
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service