Publication: Current evidence and applications of photodynamic therapy in dermatology
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Date
2014
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Published Version
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Dove Medical Press
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Citation
Wan, Marilyn T., and Jennifer Y Lin. 2014. “Current evidence and applications of photodynamic therapy in dermatology.” Clinical, Cosmetic and Investigational Dermatology 7 (1): 145-163. doi:10.2147/CCID.S35334. http://dx.doi.org/10.2147/CCID.S35334.
Research Data
Abstract
In photodynamic therapy (PDT) a photosensitizer – a molecule that is activated by light – is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.
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Keywords
photodynamic therapy, skin cancer, actinic keratosis, acne, aminolevulinic acid, methylaminolevulinate
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