Publication: Discovering cancer immunotherapy targets in vivo
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Date
2014
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Published Version
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Volume Title
Publisher
Landes Bioscience
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Citation
Zhou, Penghui, and Kai W Wucherpfennig. 2014. “Discovering cancer immunotherapy targets in vivo.” Oncoimmunology 3 (1): e28500. doi:10.4161/onci.28500. http://dx.doi.org/10.4161/onci.28500.
Research Data
Abstract
A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.
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Keywords
cancer, T cell, therapeutic targets, RNAi screen, tumor microenvironment
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