Publication: The Aging Kidney: Increased Susceptibility to Nephrotoxicity
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Date
2014
Published Version
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Publisher
MDPI
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Citation
Wang, Xinhui, Joseph V. Bonventre, and Alan R. Parrish. 2014. “The Aging Kidney: Increased Susceptibility to Nephrotoxicity.” International Journal of Molecular Sciences 15 (9): 15358-15376. doi:10.3390/ijms150915358. http://dx.doi.org/10.3390/ijms150915358.
Research Data
Abstract
Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair.
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Keywords
aging, acute kidney injury (AKI), chronic kidney disease (CKD), nephrotoxicity
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