Publication: Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes
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Date
2014
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Springer US
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Citation
Middelbeek, Roeland J. W., Tamarra James-Todd, Mary-Elizabeth Patti, and Florence M. Brown. 2014. “Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes.” Obesity Surgery 24 (9): 1442-1446. doi:10.1007/s11695-014-1228-8. http://dx.doi.org/10.1007/s11695-014-1228-8.
Research Data
Abstract
Background: In severely obese type 2 diabetes patients, gastric bypass surgery (GB) reduces body mass index (BMI) and hemoglobin A1c (HbA1c) and allows reduced doses of insulin and other medications. Data regarding the effects of GB on severely obese patients with type 1 diabetes are limited. Methods: Severely obese women with type 1 diabetes (n = 9) were studied immediately before and after GB (7.7 ± 5.8 weeks, mean ± SD). Results: On average, GB reduced mean BMI by 11 % and mean HbA1c by 0.9 % (from 8.0 to 7.1 %), with a parallel 38 % decrease in basal insulin requirements (expressed per kilogram of body weight). Conclusion: GB rapidly decreased BMI, HbA1c, and insulin requirements in severely obese women with type 1 diabetes. However, physiologic insulin replacement remains necessary in patients with type 1 diabetes.
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Keywords
Gastric bypass surgery, Type 1 diabetes, Insulin requirements
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